Use of High Content Analysis in Toxicologic Clinical Pathology for Identification and Monitoring of Translational Safety Biomarkers
Peter O’Brien, DVM, PhD, DVSc Advanced Diagnostics Laboratory Staff Clinical Pathologist, Veterinary Hospital Director, Advanced Diagnostics Laboratory, NovaUCD University College of Dublin Margarida Canelas Domingos, Vet Med Clinical Pathology Resident, Veterinary Hospital University College Dublin
Summary
High content analysis is a novel technology of high relevance to toxicologic clinical pathology for identification and monitoring of translational safety biomarkers. This technology provides consolidation, automatization and expansion of existing microscopic, morphological, and
cytochemical methods used by toxicologic clinical pathologists to assess pathological effects on blood cells or other tissue cells acquired by biopsy. HCA may have wider application across drug discovery and development than other translation biomarkers have had, because it translates from in vitro testing, across preclinical animal testing, and into clinical testing.
This article was published in the February/March 2010 issue of International Drug Discovery, Volume 5, Issue 1, on pgs. 50-55.
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