International Drug Discovery: A Russell Publishing Publication

August/September 2006

Articles

• Miniaturization in HTS: From Concept to Implementation

  Christian Bergsdorf, Ph.D. and Ulf Bömer, Ph.D.
  Department of Assay Development and High- Throughput Screening
  Enabling Technologies, RCE
  Schering AG
  

• A Comparison of p38 Inhibitor-Protein Structures

  ¹Arthur M. Doweyko, Ph.D. and ²Stephen T. Wrobleski, Ph.D.
  Departments of ¹Molecular Biosciences and ²Discovery Chemistry Bristol-Myers Squibb

• Outsourcing Drug Discovery Chemistry: Project Planning for Positive Impact

  Robert A. Goodnow, Jr., Ph.D.
  Roche Research Center

• Automated High Throughput Drug Target Crystallography

  Bernhard Rupp, Ph.D.
  Macromolecular Crystallography and TB Structural Genomics Consortium, University of California, Irvine

• Global Metabolic Profiling and Systems Biology in Toxicology Research and Testing

  Laura K. Schnackenberg, Ph.D. and Richard D. Beger, Ph.D.
  Division of Systems Toxicology, National Center for Toxicological Research, Food and Drug Administration

• A Common Platform HTS Approach to ADME Profiling in Lead Generation and Lead Optimization

  Norman D. Huebert, Ph.D.
  Johnson & Johnson Pharmaceutical Research & Development

• Capitalizing On and Enhancing Wyeth's Compound Collection

  Lee D. Jennings, Ph.D.
  Wyeth

• Cancer Immunotherapy Using RNAi Technology

  ¹Chih-Ping Mao, ^1,2Chien-Fu Hung, Ph.D and ^1-4T-C Wu, Ph.D.
  ¹Departments of Pathology, ²Oncology,³Obstetrics and Gynecology, ⁴Molecular Microbiology and Immunology, Johns Hopkins Medical Institutions

• Implementing hERG Screening Early in the Preclinical Drug Discovery Process

  John Dunlop and Mark Bowlby
  Neuroscience Discovery Research, Wyeth Research